Lamisil
Lamisil (generic name: Terbinafine) is an antifungal agent that is taken by mouth or applied to the skin. Terbinafine acts by interfering with the ability of fungi to make chemicals called sterols that are an important part of the membrane that surrounds fungal cells and holds them together. This weakens the cell membrane. Oral Lamisil terbinafine is more effective for treating fungal nail infections than griseofulvin (Fulvicin; Gris-Peg) and itraconazole (Sporanox), two other antifungal agents used for treating fungal nail infections. Topical terbinafine was approved by the FDA in 1993. Lamisil Terbinafine oral tablets were approved in 1996.
Rifampin reduces terbinafine blood concentrations, potentially reducing the efficacy of terbinafine, and cimetidine (Tagamet) may increase terbinafine blood levels. The latter effect would not be expected to lead to problems.
Lamisil side effects
Laimisil is a very safe medication. The need to discontinue therapy because of side effects is quite rare. The most frequently reported side effects are diarrhea, and abdominal pain. Increases in liver enzymes, hives, itching and altered taste sensation also have been observed.
